definition, vitamin C, what is the interest?

Vitamin C, magnesium… Liposomal technology involves encapsulating a substance in a liposome. What exactly is this? What is the difference between the conventional pharmaceutical form? Better efficiency? Are there any risks and contraindications?

Definition: What does liposomal mean?

The term “liposomal” means a A substance encapsulated in a liposome. It is a small, artificially formed spherical vesicle with a lipid outer wall (consisting ofFatty acids) and an aqueous inner cavity (consisting of water). Depending on the lipophilic or hydrophilic properties, the material will be incorporated into the wall or cavity to be transported in the body. This process can be used to formulate a medicine, a supplement and medical device (ophthalmic solution, intimate gel, etc.).

What is the benefit of using the drug in the form of liposomes?

Unlike conventional drugs, a liposomal drug has a better bioavailability (the part of the active substance that reaches its purpose of action through the blood). Similarly, in the case of oral forms, this system allows the transport of the active substance in the body. protecting it from being destroyed by acidic pHstomach and enzymes. In fact, liposomal technology has an advantage reduce the frequency and dosage of the drug while maintaining the same effectiveness, which allows limiting unwanted effects. For topical forms, effectiveness is prolonged thanks to the liposome, which gradually releases the active substance.

What are the benefits of liposomal vitamin C?

The vitamin C Liposomal has the same benefits as classic vitamin C:

  • antioxidant effect
  • reducing fatigue
  • maintenance of physiological functions
  • production collagen necessary to maintain the integrity of blood vessels, bones, cartilage, gums, teeth and skin
  • contributes to functioning nerve systemimmune system and energy metabolism

However, liposomal vitamin C is better absorbed in the intestine and better preserved in the body due to its fat solubility. Most of the classic vitamin C (water soluble) is eliminated in the urine. Therefore, liposomal vitamin C is present in higher concentrations in the body, and its effect is enhanced. Furthermore, the encapsulation of vitamin C into a liposome promotes better gastrointestinal tolerance. Indeed, stomach acidity, intestinal gas and diarrhea is reported only in the classic form.

What are the benefits of liposomal magnesium?

Magnesium supplements have several health benefits:

  • preventosteoporosispromotes bone growth and normal teeth by helping to fix calcium on bones
  • generate energy and fight fatigue
  • regulate stress and sleep
  • improve concentration intellectual
  • contribute to the good muscle function
  • prevent cardiovascular disorders

In liposomal form, to magnesium is better tolerated. Unlike ordinary magnesium, it does not irritate the intestinal mucosa, so digestive disorders (abdominal pain, diarrhea) occur less often. In addition, the liposomal form is associated with a better stomach tolerance due to the lack of interaction with gastric acids. Liposomal magnesium is accumulates better in the body and is better absorbed in the intestines. So it is present in higher concentrations in the body, so it has a better efficacy than the classic form at equivalent doses.

What are the disadvantages or risks of the liposomal formulation?

Use of the liposomal form may cause take too large doses vitamins or trace elements compared to official recommendations. Here is risk of overdose patients changing the classical form in liposomal form. When switching from one form to another, the dose must be changed, because the rate of absorption of the active substance is not the same. In addition, some people find it difficult to swallow the liposomal product due to the unpleasant taste or the large size of the capsules. Also liposomal drug form is much more expensive than the classical form. Due to the more complex development of the industry, the price can vary by 3 to 4 times between two deliveries. Finally, using a natural material can limit the absorption of additives commonly used in liposome formulation.

Therefore, one should be careful about the liposomal form, which releases a higher concentration in the body.

Who is forbidden?

The liposomal form has no special contraindications, except allergy to one of the product components. Other contraindications are not related to the liposome, they are specific to the active substance, vitamin or trace element used. For example, no more than 1 gram of liposomal vitamin C should be given in moderate to severe renal failureas well as classic vitamin C. Therefore, one must be vigilant about the liposomal form that is released higher concentration in the body.

Sources:
– Copmed laboratory
– Alesco Laboratory
– Academy of Medicine
Ascorbic acid encapsulated in liposomes: effect on vitamin C bioavailability and its ability to protect against ischemia-reperfusion injury in 2016 June 20, National Library of Medicine

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