Lack of vitamin D? This can be the cause of chronic inflammation

Here’s (another) good reason to make sure you’re getting enough vitamin D. This fat-soluble (soluble) vitamin is already known to play an essential role in the intestinal absorption of calcium and phosphorus and to promote bone strengthening. . It is synthesized in the skin exposed to sunlight. It is also provided by food, mainly fatty fish (cod liver, herring, mackerel), offal, butter, egg yolk, whole milk. Now researchers from the University of South Australia have found a link between low levels of vitamin D and chronic inflammation. Inflammation is generally a beneficial response of the body, as it allows the body to defend itself against the attack and repair the damaged tissue: we speak of the “acute” inflammatory response. But when it persists and becomes chronic, it can contribute to a host of complex diseases, including type 2 diabetes, heart disease, and autoimmune disease.

Studio published in International Journal of Epidemiology shows a direct link between low vitamin D levels and high levels of inflammation, an important biomarker for identifying those at risk for chronic diseases with an inflammatory component. This is because people with high levels of inflammation are more likely to have high levels of a substance called C-reactive protein. The researchers therefore examined the genetic data of 294,970 UK Biobank participants to identify a possible link between vitamin D level and C-reactive protein, a prominent indicator of inflammation. “ Inflammation is your body’s way of protecting tissue if you’ve been injured or have an infection. explains Dr. Ang Zhou, lead author of the study. “High levels of C-reactive protein are produced by the liver in response to inflammation, so when the body experiences chronic inflammation, it also shows higher levels of C-reactive protein.. »

What is proper vitamin D status?

The results suggest that increasing vitamin D in deficient people can reduce chronic inflammation. “ This study examined vitamin D and C-reactive protein and found a unidirectional association between low vitamin D levels and high C-reactive protein levels, expressed in inflammation. An increase vitamin D in people with deficiencies, it can reduce chronic inflammation and help prevent many related diseases. “, the scientist adds. The research, supported by the National Health and Medical Research Council (Australia’s medical research funding body), also raises the possibility that adequate levels of vitamin D may alleviate obesity-related complications and reduce the risk or severity of disease. an inflammatory component, such as cardiovascular disease, diabetes, and autoimmune diseases (which occur when the immune system malfunctions, causing it to attack the body).

Also discover: vitamin D, an essential substance for the body

However, based on this observation, the researchers note that there are some contradictions regarding the links with vitamin D. That is why they emphasize that supplements should only be done under the direction of a doctor and when a deficiency is diagnosed. through a blood test. ” We have seen it many times evidence of health benefits is associated with increased vitamin D levels in people with very low levels of vitamin D and little or no benefit in others. “, they point out. However, although these results need to be confirmed by further studies, the research team believes that they have the advantage of highlighting “ it is important to avoid vitamin D deficiency and to provide further evidence of its widespread effects. » Please note that according to nutritional guidelines from ANSES*, adequate vitamin D intake is defined as 15 µg/d or more in children 1 year of age and older, adolescents, adults, and pregnant women. Deficiency symptoms include rickets in children and bone decalcification in adults.

It refers to a change in bone mineralization due to decreased absorption of calcium and phosphorus. Additionally, “ a vitamin D deficiency reduces bone mineral density, and older people, especially women, are prone to osteoporosis. ANSES notes. If vitamin D is synthesized by epidermal cells from cholesterol under the influence of ultraviolet rays, this synthesis depends on many factors: latitude, season, age, skin pigmentation, clothing and use. sun protection. It turns out that in France, more than half of the French are vitamin D deficient A study by Inserm. However, the same study identified three simple measures to be taken to achieve the right ratio: physical activity, light daily exposure to the sun and maintaining a normal weight. However, a doctor’s advice is necessary, because vitamin D accumulates in the body, and overdose can cause nausea, headaches, muscle and bone pain, heart rhythm disorders, calcium deposits in the kidneys, heart and lungs.

*National Food, Environmental and Occupational Health Safety Agency

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