Is one form of D3 more effective than another?


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  • Metabolite of vitamin D3 more effective in the elderly?Metabolite of vitamin D3 more effective in the elderly?


We told you about it last November, and it seems more and more research is confirming it more important role of vitamin D3 compared to vitamin D2 in increasing total vitamin D levels. A new study published this time last January suggests that the vitamin D3 metabolite calcifediol would be even more effective than the “classic” D3 cholecalciferol in older patients.

In this high-profile clinical trial conducted by researchers at the University of Pisa, Italy, 140 patients were divided into two separate groups. average age is 83 years admitted to the hospital who did not suffer from serious pathologies in general and who were diagnosed with vitamin D deficiency. The first group took “classic” vitamin D3 (cholecalciferol) for three months, and the second – a metabolite of this vitamin. (calcifediol). As a metabolite of D3 (ie the form of vitamin D3 when it is absorbed and then processed in our liver), calcifediol is three times more potent than cholecalciferol. Eligible patients therefore received a threefold lower dose of calcifediol to avoid falsification of the results (437.5 micrograms per week of cholecalciferol, ie 70 drops, compared to 140 micrograms per week of calcifediol, ie 28 drops), and this once a week. same day and same time (afternoon), during hospitalization and three months after discharge.

Important information for older people who are more likely to be deficient in vitamin D

At the end of the experiment a blood marker indicating mean vitamin D3 concentration was significantly higher in patients treated with metabolite D3 than in those treated with conventional D3. (mean 25-OH-vitamin D3 concentration was 45.4 ng/mL in the calcifediol group compared with 30.7 ng/mL in the cholecalciferol group). This information is particularly interesting because the oldest among usespecially men over 55, are those who most suffer from vitamin D deficiencyespecially when it is rare to be outside and it is not allowed to sunbathe from April to September, during which this vitamin can be “recharged” from 80 to 90 percent.

Some critical observers explain that this type of vitamin D, if it allows a rapid increase in vitamin D levels in the blood, would also decrease the same amount faster than regular D3. While waiting for science to decide more formally, you can form your own opinion by discussing it with your doctor. This vitamin D3 metabolite actually exists prescription onlybecause it is considered a medicine because of its potency.


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Source :

A randomized, open-label trial to evaluate the efficacy of weekly cholecalciferol and calcifediol in elderly patients with hypovitaminosis D », Geriatricsin 2022 month of January.

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