study shows the effectiveness of vitamin D in limiting the number of deaths in the elderly

The results, released on Tuesday, conclude that taking a high dose of vitamin D within 72 hours of being diagnosed with COVID-19 significantly reduces the risk of death.

The results of the COVIT-TRIAL study, published in the journal, were presented on Tuesday, 31 May Plos medicine to capture the efficacy of vitamin D in limiting the mortality of Covid-19 in the elderly.

“This result is important and is in line with what we knew about the anti-inflammatory effects of vitamin D, which greatly reduces the risk of death after 14 days and clearly avoids the escape of inflammation,” he writes. Press release Professor Cédric Annweiler, Head of the Department of Geriatrics at the University Hospital of Angers, in charge of the study.

The route considered since the beginning of the epidemic

From the outset of the COVID-19 epidemic, traces of vitamin D have emerged in the medical profession as a potential treatment to limit the effects of infection. So Cédric Annweiler remembers that already in 2020. March. considered this possibility because of the properties of the vitamin that were known at the time.

Synthesized in the human body during sunlight, vitamin D is known for its anti-inflammatory effects in infectious and cancerous diseases. Specifically, Covid-19 uses an ACE2 protein that is deregulated to enter the human body. However, vitamin D has the opposite effect. It regulates ACE2 expression and therefore limits the effects of Covid-19 in humans.

“That’s why we quickly imagined it, already in 2020. “Vitamin D can help fight serious forms of Covid-19,” added Professor Annweiler.

Study entitled “National Research Priority”

2020 The COVIT-TRIAL study was launched in April as a national research priority to assess the effects of high vitamin D intake on mortality in patients with Covid-19, as well as the safety of high vitamin intake.

To do this, in 2020. April-December 260 patients were observed in nine French hospitals. Angers, Bordeaux, Limoges, Nantes, Nice, Saint-Étienne, Tours, Le Mans and Saumur, as well as nursing homes depending on these institutions.

The patients selected were 65 years of age or older with an ‘unfavorable outcome criterion’ or 75 years of age or older. All with Covid-19.

These volunteers were then divided into two groups. Those who received a high dose of vitamin D within 72 hours of diagnosis and those who received a regular dose. From day 6 of treatment, the results were convincing. Doctors observed a “significant and statistically significant reduction in the risk of death” in the high-dose vitamin D group.

The effect on mortality persists for 14 days, with no adverse effects associated with high vitamin D intake. Only after 28 days the effectiveness decreases.

Disadvantage that can be considered a comorbidity

Results leading to a clear conclusion. The authors of the study recommend the early administration of a high dose of vitamin D, which is described as a “simple and safe treatment” for elderly people infected with Covid-19. Especially since vitamin D also helps regulate cellular immunity.

More broadly, vitamin D deficiency in a patient may be a concomitant disease of Covid-19, as can obesity. Other than that, unlike the latter, vitamin D deficiency can be cured quickly. “Hypovitaminosis (deficiency, ed. Note) D is a risk factor that can be very easily modified with simple supplements,” the study said in a press release.

The results give hope to several thousand patients still hospitalized in France for Covid-19 on June 1st. – 14 850. “If the last wave The Covid-19 epidemic is declining“Patients with Covid-19, especially the oldest, never stop being hospitalized,” the press release warned.

Leave a Comment