In the event of a pandemic, there has been much and right talking about the importance of vitamin D in reducing the severe complications of COVID-19. Indeed, several studies have shown that Less Vitamin D is associated with an increased risk of developing severe forms of COVID-19. And die from the disease.
For example, a recent study reports that patients with COVID-19 who develop hypovitaminosis D are 4-fold more likely to die.
Vitamin D against cancer and recurrence
These impressive figures clearly underline the importance of vitamin D for health. Especially when it comes to cancer-related mortality. Numerous studies have shown that vitamin D has a wide range of direct (inhibit cell growth) or indirect (immunomodulatory, anti-inflammatory, anti-angiogenic) anti-cancer effects.
All of these effects can slow the progression of cancer and prevent advanced and invasive forms of the disease, including metastases. This protective effect has obvious clinical benefits. For example, a study showed that women with breast cancer who did not have enough vitamin D (<50 nmol / L) were almost twice as likely to recur and die from the disease.
Less serious cancers and metastases
Recent results from a clinical study suggest a better assessment of this link between vitamin D and cancer risk. In this double-blind study, 12,938 men and women 50 years of age and older were randomly assigned to one of 2 groups.
Consider the placebo group and the intervention group that received 2,000 IU of vitamin D3 supplementation per day. For a period of five years. The researchers later listed cancer in both groups of participants.
Overall, the researchers found no significant difference between the cancer groups in the two groups. On the other hand, and here the results are interesting, they observed a significant (17%) reduction in advanced and metastatic cancer among participants in the vitamin D group. significant (38%) in thin subjects (BMI <25).
However, in obese people (BMI 25-29) it becomes insignificant (11%) and in obese people (BMI ≥ 30) it disappears completely.
Obesity plays a protective role against vitamin D.
Vitamin D is soluble in fat. Therefore, it is likely that excess fat in overweight people creates a vitamin reservoir. Thus, its concentration in the blood decreases. Another possibility is that the immune system of obese people is often unregulated (especially cells that specialize in removing cancer cells). These changes reduce the immunomodulatory effects of vitamin D.
Long-term maintenance of vitamin D3