Vitamin D protects against cardiovascular disease and stroke

Vitamin D, also known as the “sun” vitamin, is a fat-soluble vitamin that exists in two main forms: D-2 and D-3. Vitamin D, as an essential trace element and is obtained mainly from sunlight, is important for the development of bones and teeth and for the regular functioning of the immune system.

In addition to these features, previous studies have shown an association between low vitamin D levels and a higher risk of developing cardiovascular disease. In a new study, researchers found that testing vitamin D levels is helpful in assessing the risks to the human cardiovascular system.

Cardiovascular disease (CVD) is one of the leading causes of death worldwide. It is estimated that 17.9 million people worldwide die from complications of heart disease each year. In terms of context, this means that IDUs account for 32% of all deaths worldwide.

Previous research suggests that a variety of factors, such as multiple health conditions, age, family history, diet, and lifestyle, together influence the risk of developing COCs. Using a new analytical method, Australian researchers have discovered an additional factor that could increase the likelihood of human cardiovascular disease.

Researchers have found evidence that vitamin D deficiency can increase blood pressure and the risk of cardiovascular disease. However, an increase in vitamin D benefits only those participants who “need” it. The added benefits of increasing concentrations in excess of nutritional needs will be small, if any. The results of the study are published in the European Heart Journal.

An interesting new approach

In a recent study, the researchers looked at whether there was a link between serum levels of 25-hydroxyvitamin D or 25 (OH) D and the risk of developing CVD.
Serum levels of 25 (OH) D are indicative of vitamin D status. To test their hypothesis, the researchers used a special analytical method to analyze data from the UK Biobank. This is a large prospective cohort study involving UK residents over the age of 37 years. and 73.

Participants have been recruited from 22 assessment centers across the UK since 2006. March 13 until 2009 October 1 They completed questionnaires that provided general information on health and lifestyle and provided blood samples for biomarker and genetic analysis.

In the study, a team of researchers limited the analysis of the data to unrelated individuals who were identified as white British based on self-report and genetic profiling. After screening, the study group performed genetic studies among individuals with detailed information on 25 (OH) D levels. For safety reasons, they also collected variables (including age, sex, and sampling time) that may affect serum 25 (OH) D measurements. In total, the researchers collected this information from 295,788 participants.

What do the results say?

The researchers compared the results with those of a control group that had not been diagnosed with CHD. The study group also performed a secondary analysis to investigate the relationship between 25 (OH) D concentration levels and blood pressure. The researchers report that the average level of 25 (OH) D among the 267,980 subjects was 50 nanomolar per liter (nmol / l).

They also note that:

Concentrations of less than 25 nmol / l were observed in 11.4% (32,868) of participants
Concentrations of 41.3% (119,243) participants ranged from 25 to 49.9 nmol / L.
The concentration of 35.3% (101,848) participants ranged from 50 to 74.9 nmol / l.
Concentrations of 10.5% (30,314) participants ranged from 75 to 99.9 nmol / L.
The concentration of 1.4% (4,110) participants ranged from 100 to 124.9 nmol / l.
Concentrations of 25 (OH) D in less than 0.1% of participants were greater than 125 nmol / l.

Further analysis revealed that people with a serum level of 25 (OH) D of 25 nmol / l had an 11% higher risk of developing CVD than people with a level of 50 nmol / l. However, the likelihood of CVD appears to decrease at higher concentrations. For example, participants at a concentration of 75 nmol / l were 2% less likely to develop CVD than participants at a concentration of 50 nmol / l.

Researchers call this phenomenon a nonlinear association, where a change in the value of one entity does not always correspond to a constant change in the value of another entity. The researchers observed similar nonlinear associations between 25 (OH) D levels and participants’ blood pressure levels. At 25 nmol / l, they observed a marked increase in blood pressure compared to 50 nmol / l. These results led researchers to conclude that vitamin D deficiency may increase the risk of CHD.

Finally, the advice you get from this test is to check your vitamin D levels with your doctor. If vitamin D levels are found to be very low, there is now evidence that increasing these levels will reduce the risk of cardiovascular disease, including coronary heart disease and stroke.

Source

A nonlinear randomized analysis of Mendel confirms the effect of vitamin D deficiency on the risk of cardiovascular disease. European Heart Magazine

* Presse Santé aims to communicate health knowledge in a language accessible to all. Under no circumstances should the information provided replace the advice of a healthcare professional.

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