Vitamin D, omega-3 and exercise for cancer prevention

According to a randomized survey published in 2022. in April Limits of aging.

The risk of cancer increases with age. It is the second most common cause of death in the elderly.

In addition to preventive recommendations such as not smoking and sun protection, public health efforts to prevent cancer are limited, emphasizes the first author, Heike Bischoff-Ferrari of the University Hospital of Zurich.

Efforts to prevent middle-aged and older people are now limited to screening and vaccination.»

Mechanistic studies have shown that vitamin D inhibits the growth of cancer cells. Also, Omega 3 can inhibit transformation cells normal cells cancersand exercise improves immune function and reduces itinflammationwhich can help prevent cancer.

However, there is a lack of clinical trials demonstrating the efficacy of these three interventions, alone or in combination.

To fill this gap, Bischoff-Ferrari and his colleagues conducted a randomized study over three years in five European countries (Germany, Austria, France, Portugal and Switzerland), with 2157 participants.

They tested the effects of a high daily dose of the supplement vitamin D3 (2000 IU per day, with current recommendations being 800 IU), replenished daily omega-3 of marine origin (1 g per day) and a home resistance exercise program (3 times per week), individually and in combination, to reduce the risk of invasive cancer in 2,157 people aged 70 and over in five European countries (Switzerland, France, Germany, Austria). and Portugal).

Participants were randomly divided into eight groups to test the individual and overall benefits of the interventions. One group received placebo alone.

Participants who were followed for 3 years received follow-up telephone calls every three months and were screened at the study centers at the beginning of the study, in the first, second, and third years.

All three treatments had an overall positive effect on the risk of invasive cancer. Each individually provided a small benefit, but the combination of the three treatments became a benefit statistically significantand the overall risk decreased by 61%. (The difference between absolute risk and relative risk)

In the triple combination, 35 people had to be treated to avoid one case of cancer in 3 years of follow-up.

However, the three-year period is short to assess the impact on cancer risk, as they often develop over a long period of time. Future studies should test the benefits over longer observation periods and with a larger number of participants to improve statistical power.

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Psychomedia with sources: Border science news, Limits of aging.
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